解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Although Ernest Shackleton's Endurance Antarctic expedition of 1914 to 1916 is a famous epic of survival, the medical achievements of the two expedition doctors have received little formal examination. Marooned on Elephant Island after the expedition ship sank, Drs. Macklin and McIlroy administered a chloroform anesth...
journal_title:Anesthesiology
pub_type: 历史文章,杂志文章
doi:10.1097/ALN.0000000000001151
更新日期:2016-07-01 00:00:00
abstract::Robert D. Dripps, M.D. (1911 to 1973), helped found academic anesthesiology. Newly reviewed teaching slides from the University of Pennsylvania (Philadelphia, Pennsylvania) contain six anesthesia records from 1965 to 1967 that involved Dripps. They illustrate the clinical philosophy he taught-to consider administratio...
journal_title:Anesthesiology
pub_type: 传,历史文章,杂志文章
doi:10.1097/ALN.0000000000001109
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Hypoalbuminemia may increase the risk of acute kidney injury (AKI). The authors investigated whether the immediate preoperative administration of 20% albumin solution affects the incidence of AKI after off-pump coronary artery bypass surgery. METHODS:In this prospective, single-center, randomized, parallel-...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000001051
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Anesthetic preconditioning (APC) is a clinically important phenomenon in which volatile anesthetics (VAs) protect tissues such as heart against ischemic injury. The mechanism of APC is thought to involve K channels encoded by the Slo gene family, and the authors showed previously that slo-2 is required for A...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001046
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Propofol (2,6-diisopropylphenol) is one of the most frequently used anesthetic agents. One of the main side effects of propofol is to reduce blood pressure, which is thought to occur by inhibiting the release of catecholamines from sympathetic neurons. Here, the authors hypothesized that propofol-induced hyp...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001015
更新日期:2016-04-01 00:00:00
abstract::The proclamation, "Gentlemen! this is no humbug," attributed to John Collins Warren, M.D., was not identified in any contemporaneous eyewitness report of William T. G. Morton's October 16, 1846, demonstration of ether at Massachusetts General Hospital. The earliest known documentation of the proclamation is in Nathan ...
journal_title:Anesthesiology
pub_type: 传,历史文章,杂志文章
doi:10.1097/ALN.0000000000000944
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Hypotension is a common side effect of general anesthesia induction, and when severe, it is related to adverse outcomes. Ultrasonography of inferior vena cava (IVC) is a reliable indicator of intravascular volume status. This study investigated whether preoperative ultrasound IVC measurements could predict h...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001002
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Identifying functionally relevant anesthetic-binding sites in pentameric ligand-gated ion channels (pLGICs) is an important step toward understanding the molecular mechanisms underlying anesthetic action. The anesthetic propofol is known to inhibit cation-conducting pLGICs, including a prokaryotic pLGIC from...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001005
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Cardiac surgery requiring cardiopulmonary bypass is associated with platelet activation. Because platelets are increasingly recognized as important effectors of ischemia and end-organ inflammatory injury, the authors explored whether postoperative nadir platelet counts are associated with acute kidney injury...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000959
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Postoperative cognitive dysfunction is common, but it remains unclear whether there are long-term adverse cognitive effects of surgery combined with anesthesia. The authors examined the association between exposure to surgery and level of cognitive functioning in a sample of 8,503 middle-aged and elderly twi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000957
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Surgical resection remains the best option for long-term survival in many solid tumors. Surgery can, however, lead to tumor cell release into the circulation. Data have suggested differential effects of anesthetic agents on cancer cell growth. This retrospective analysis investigated the association of anest...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000936
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:In the event of trauma, emergency reversal of anticoagulation therapy may be required. However, no specific reversal agents are routinely available for the direct oral anticoagulants such as dabigatran. The authors investigated four-factor prothrombin complex concentrate (PCC) for treating dabigatran-induced...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000863
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Management of cardiovascular implantable electronic devices (CIEDs), including pacemakers and implantable cardioverter defibrillators, for surgical procedures is challenging due to the increasing number of patients with CIEDs and limited availability of trained providers. At the authors' institution, a small...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000838
更新日期:2015-11-01 00:00:00
abstract::[This corrects the article on p. 1281 in vol. 121, issue 6, PMID: 25072223.]. ...
journal_title:Anesthesiology
pub_type: 已发布勘误
doi:10.1097/01.anes.0000470960.33159.09
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Neosaxitoxin (NeoSTX) is a site-1 sodium channel blocker that produces prolonged local anesthesia in animals and humans. Under a Food and Drug Administration-approved phase 1 Investigational New Drug trial, the authors evaluated safety and efficacy of NeoSTX alone and combined with 0.2% bupivacaine (Bup) wit...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000000831
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Neuroligin-1 (NL1) forms a complex with the presynaptic neurexin-1β (Nrx1b), regulating clustering of N-methyl-D-aspartate receptors with postsynaptic density-95 (PSD-95) to underlie learning-/memory-associated plasticity. Pain-related spinal neuroplasticity shares several common features with learning-/memo...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000809
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Dyspnea, like pain, can cause major suffering in intensive care unit (ICU) patients. Its evaluation relies on self-report; hence, the risk of being overlooked when verbal communication is impaired. Observation scales incorporating respiratory and behavioral signs (respiratory distress observation scales [RDO...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000805
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Isoflurane induces cell death in neurons undergoing synaptogenesis via increased production of pro-brain-derived neurotrophic factor (proBDNF) and activation of postsynaptic p75 neurotrophin receptor (p75). Astrocytes express p75, but their role in neuronal p75-mediated cell death remains unclear. The author...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000824
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Impaired cardiac repolarization, indicated by prolonged QT interval, may cause critical ventricular arrhythmias. Many anesthetics increase the QT interval by blockade of rapidly acting potassium rectifier channels. Although xenon does not affect these channels in isolated cardiomyocytes, the authors hypothes...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/ALN.0000000000000764
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Mice lacking calsequestrin-1 (CASQ1-null), a Ca-binding protein that modulates the activity of Ca release in the skeletal muscle, exhibit lethal hypermetabolic episodes that resemble malignant hyperthermia in humans when exposed to halothane or heat stress. METHODS:Because oxidative species may play a criti...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000748
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:To minimize the risk of pneumonia, many anesthesiologists delay anesthesia-requiring procedures when patients exhibit signs of viral upper respiratory tract infection. Postinfluenza secondary bacterial pneumonias (SBPs) are a major cause of morbidity and mortality. An increased host susceptibility to SBP pos...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000766
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Glucose-insulin-potassium (GIK) administration during cardiac surgery inconsistently improves myocardial function, perhaps because hyperglycemia negates the beneficial effects of GIK. The hyperinsulinemic normoglycemic clamp (HNC) technique may better enhance the myocardial benefits of GIK. The authors exten...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000000723
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:The authors conducted a randomized, controlled, parallel-arm, superiority study to test the hypothesis that a continuous adductor canal block decreases the time to attain four discharge criteria compared with a continuous femoral nerve block after tricompartment knee arthroplasty. METHODS:Subjects undergoin...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/ALN.0000000000000741
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Neuropathic pain is a condition resulting from injury to the peripheral and/or central nervous system. Despite extensive research over the last several decades, neuropathic pain remains difficult to manage. METHODS:The authors conducted a randomized, placebo-controlled, double-blinded, and crossover clinica...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000000693
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:In an effort to measure and improve the quality of perioperative care, the Surgical Care Improvement Project (SCIP) was introduced in 2003. The SCIP guidelines are evidence-based process measures designed to reduce preventable morbidity, but it remains to be determined whether SCIP-measure compliance is asso...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000681
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Transfusion-related acute lung injury incidence remains the leading cause of posttransfusion mortality. The etiology may be related to leukocyte antibodies or biologically active compounds in transfused plasma, injuring susceptible recipient's lungs. The authors have hypothesized that transfusion could have ...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000000689
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Drugs used for sedation in anesthesia and intensive care may cause pharyngeal dysfunction and increased risk for aspiration. In this study, the authors investigate the impact of sedative doses of morphine and midazolam on pharyngeal function during swallowing and coordination of breathing and swallowing. ME...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000657
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:It has been known that skeletal muscles show atrophic changes after prolonged sedation or general anesthesia. Whether these effects are due to anesthesia itself or disuse during anesthesia has not been fully clarified. Autophagy dysregulation has been implicated in muscle-wasting conditions. This study teste...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000561
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The current study was designed to test the hypothesis that the fibromyalgia survey criteria would be directly associated with increased opioid consumption after hysterectomy even when accounting for other factors previously described as being predictive for acute postoperative pain. METHODS:Two hundred eigh...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000637
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Adaptive support ventilation can speed weaning after coronary artery surgery compared with protocolized weaning using other modes. There are no data to support this mode of weaning after cardiac valvular surgery. Furthermore, control group weaning times have been long, suggesting that the results may reflect...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000000589
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Chronic postsurgical pain, a significant public health problem, occurs in 10 to 50% of patients undergoing major surgery. Acute pain induces endogenous analgesia termed conditioned pain modulation (CPM), and the strength of CPM preoperatively predicts the likelihood of chronic postsurgical pain. The relation...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000593
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Propofol is widely used clinically for the induction and maintenance of anesthesia. Clinical case reports have shown that propofol has an antiatrial tachycardia/fibrillation effect; however, the related ionic mechanisms are not fully understood. The current study investigates the effects of propofol on human...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000495
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Cardiac surgery requiring the use of cardiopulmonary bypass is frequently complicated by coagulopathic bleeding that, largely due to the shortcomings of conventional coagulation tests, is difficult to manage. This study evaluated a novel transfusion algorithm that uses point-of-care coagulation testing. MET...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000556
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:There is an unmet clinical need to develop a pharmacological therapy to counter opioid-induced respiratory depression without interfering with analgesia or behavior. Several studies have demonstrated that 5-HT1A receptor agonists alleviate opioid-induced respiratory depression in rodent models. However, ther...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000490
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Systemic inflammation is a key feature in acid aspiration-induced acute respiratory distress syndrome (ARDS), but the factors that trigger inflammation are unclear. The authors hypothesize that extracellular histones, a newly identified inflammatory mediator, play important roles in the pathogenesis of ARDS....
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000429
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Multicapillary column ion-mobility spectrometry (MCC-IMS) may identify volatile components in exhaled gas. The authors therefore used MCC-IMS to evaluate exhaled gas in a rat model of sepsis, inflammation, and hemorrhagic shock. METHODS:Male Sprague-Dawley rats were anesthetized and ventilated via tracheost...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000420
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Liver damage by ischemia and reperfusion injury is a risk factor for morbidity and mortality after liver surgery. Postoperative oxygen treatment is routinely applied in the postanesthesia and intensive care unit after liver surgery. The risks of aggravating the injury by increasing inspiratory oxygen from 21...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000447
更新日期:2014-12-01 00:00:00
abstract::Critically ill patients often suffer from multiple organ failures involving lung, kidney, liver, or brain. Genomic, proteomic, and metabolomic approaches highlight common injury mechanisms leading to acute organ failure. This underlines the need to focus on therapeutic strategies affecting multiple injury pathways. Th...
journal_title:Anesthesiology
pub_type: 杂志文章,评审
doi:10.1097/ALN.0000000000000446
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Hydroxyethyl starch (HES) is commonly used as plasma expander during surgery but may be nephrotoxic as seen in studies in patients with sepsis. The authors hypothesized that the possible nephrotoxicity of 6% HES 130/0.4 could be revealed by measurements of urinary excretion of neutrophil gelatinase-associate...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000000413
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Whether intraoperative use of hydroxyethyl starch impairs kidney function remains unknown. The authors thus tested the primary hypothesis that Hextend promotes renal injury in surgical patients. Secondarily, the authors evaluated the dose-outcome relationship, in-hospital and 90-day mortality, and whether th...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000375
更新日期:2014-10-01 00:00:00